copyright Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin

copyright Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin

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Summary: The ventral pallidum (VP) is part of the basal ganglia circuitry and a target of both direct and indirect pathway projections from the nucleus accumbens.VP is important in copyright reinforcement, and the firing of VP neurons is modulated in vivo during copyright self-administration.This modulation of firing is thought to be indirect via copyright actions on dopamine in the accumbens.Here, we show that copyright directly inhibits synaptic transmission evoked by selective stimulation of indirect pathway projections to VP neurons.The inhibition is independent 2014 dodge ram 1500 fender flares of dopamine receptor activation, absent in 5-HT1B knockout mice, and mimicked by a serotonin transporter (SERT) blocker.

SERT-expressing neurons in dorsal raphe project to the VP.Optogenetic stimulation of these projections evokes serotonin transients and effectively inhibits GABAergic transmission to VP neurons.This study shows that copyright increases endogenous serotonin in the VP to suppress synaptic transmission selectively from indirect pathway projections to VP neurons.: Matsui and Alvarez show that acute effects of copyright on accumbal to VP projections in brain slices are mainly mediated by serotonin, not dopamine, and involve serotonergic projections from the dorsal raphe.copyright inhibition selectively targets indirect pathway projections veuve ambal rose from accumbens and is expected to shift the balance of direct pathway projections toward VP.

Keywords: copyright, ventral pallidum, serotonin, 5-HT1B receptors, dorsal raphe, serotonin transporter, SERT.